Cervical cancer chemoprevention, vaccines, and surrogate endpoint biomarkers
نویسندگان
چکیده
منابع مشابه
Cervical cancer chemoprevention, vaccines, and surrogate endpoint biomarkers.
At the Second International Conference on Cervical Cancer, held April 11-14, 2002, experts in cervical cancer prevention, detection, and treatment reviewed the need for more research in chemoprevention, including prophylactic and therapeutic vaccines, immunomodulators, peptides, and surrogate endpoint biomarkers. Investigators and clinicians noted the need for more rigorous Phase I randomized c...
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BACKGROUND Surrogate endpoint biomarkers (SEBs) are used as intermediate indicators of a reduction in cancer incidence in chemoprevention studies. SEBs should be expressed differentially in normal and high risk tissue; appear at a well defined stage of carcinogenesis; be studied with reasonable sensitivity, specificity, and accuracy; and be modulated in chemoprevention trials. The concept of SE...
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Cervical intraepithelial neoplasia (CIN) represents a spectrum of epithelial changes that provide an excellent model for developing chemopreventive interventions for cervical cancer. Possible drug effect surrogate endpoint biomarkers are dependent on the agent under investigation. Published and preliminary clinical reports suggest retinoids and carotenoids are effective chemopreventive agents f...
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Cervical cancer chemoprevention agents under study include diet and micronutrients (particularly beta-carotene, folate, and vitamins A, C, and E); medications such as retinoids (retinyl acetate gel, all-trans-retinoic acid, and 4-hydroxyphenylretinamide) that are chemically related to micronutrients; and other chemopreventives meant to affect the carcinogenic process at the cellular level, incl...
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This perspective on Beatty et al. (beginning on page 438 in this issue of the journal) discusses the role of the immune system as nature's ultimate chemoprevention agent. A successful immune response to vaccination results in immunologic memory. In the case of a successful cancer-related response, antigen-specific T cells will be poised to destroy an aberrantly expressed protein even if the hos...
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ژورنال
عنوان ژورنال: Cancer
سال: 2003
ISSN: 0008-543X,1097-0142
DOI: 10.1002/cncr.11674